The ACVR2A antibody from MyBioSource.com is a Rabbit Polyclonal antibody to activin receptor IIA, ACTRII, ActrIIa, Acvr2, and ACVR2A. This antibody recognizes Human, Mouse, and Rat antigen. The ACVR2A antibody has been validated for the following applications: Western Blot.
Description
This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene